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Comprehensive CyTOF and lipidomic analysis of splenic immune and serum lipid responses to BCG vaccination and H37Rv challenge in BALB/c mice.

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Title: Comprehensive CyTOF and lipidomic analysis of splenic immune and serum lipid responses to BCG vaccination and H37Rv challenge in BALB/c mice.
Authors: Van-Tilbeurgh M; Université Paris-Saclay, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin- Bicêtre, Inserm, France., Yang W; Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands.; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Lopez EM; Université Paris-Saclay, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin- Bicêtre, Inserm, France., Gallouët AS; Université Paris-Saclay, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin- Bicêtre, Inserm, France., Dagg B; Vaccines Division, Medicines and Healthcare products Regulatory Agency, South Mimms, EN6 3QG, Hertfordshire, United Kingdom., Goulding S; Vaccines Division, Medicines and Healthcare products Regulatory Agency, South Mimms, EN6 3QG, Hertfordshire, United Kingdom., Keeble J; Vaccines Division, Medicines and Healthcare products Regulatory Agency, South Mimms, EN6 3QG, Hertfordshire, United Kingdom., Ho MM; Vaccines Division, Medicines and Healthcare products Regulatory Agency, South Mimms, EN6 3QG, Hertfordshire, United Kingdom., Harms A; Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands., Grand RL; Université Paris-Saclay, CEA; Immune Diseases, Microbiology and Innovative Therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin- Bicêtre, Inserm, France., Khatri B; Vaccines Division, Medicines and Healthcare products Regulatory Agency, South Mimms, EN6 3QG, Hertfordshire, United Kingdom. Bhagwati.khatri@mhra.gov.uk.
Source: Scientific reports [Sci Rep] 2026 Jun 26. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-026-58623-7