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Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates.

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Bibliographic Details
Title: Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates.
Authors: Janha O; Keltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Olaniyan N; School of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Diam GK; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Sharma S; Keltic Pharma Therapeutics Limited, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Beraldi D; School of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom., Jamieson AG; School of Chemistry Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Bozdech Z; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Tobin AB; School of Molecular Biosciences, Advanced Research Centre, University of Glasgow, Glasgow, United Kingdom., Modrzynska K; School of infection and Immunity, College of Medical, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Jun 22, pp. e0156125. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1098-6596
DOI:10.1128/aac.01561-25