Structure-based immunopharmacological design of a multi-epitope vaccine candidate against Naegleria fowleri targeting TLR3: a pan-genomic and molecular dynamics approach.

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Title: Structure-based immunopharmacological design of a multi-epitope vaccine candidate against Naegleria fowleri targeting TLR3: a pan-genomic and molecular dynamics approach.
Authors: Faizan R; Department of Pharmacology and Clinical Therapeutics, School of Medicine, University of Malaga, Malaga, 29010, Spain., Naveed M; Department of Biotechnology, Faculty of Science and Technology, University of Central Punjab, Lahore, 54000, Pakistan. dr.naveed@ucp.edu.pk., Estevez IB; Department of Pharmacology and Clinical Therapeutics, School of Medicine, University of Malaga, Malaga, 29010, Spain., Rehman HM; School of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan., Latif A; School of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan., Hammad HM; National Centre for Bioinformatics, Quaid-I-Azam University Islamabad, Islamabad, Pakistan., Khan AR; Sindh Institute of Urology and Transplantation, Karachi, Pakistan., Alsulami SO; Department of Biochemistry, Faculty of Sciences, University of Tabuk, Tabuk, 71491, Saudi Arabia., Aljumaa MA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia., Tombozara N; Institut Malgache de Recherches Appliquées (IMRA), Fondation Albert Et Suzanne Rakoto-Ratsimamanga, Avarabohitra Itaosy, PO Box 3833, Antananarivo, Madagascar. nzara89@gmail.com.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jun 28. Date of Electronic Publication: 2026 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1912
DOI:10.1007/s00210-026-05578-1