Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

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Title: Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Authors: Mader P; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Liu L; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Vallée F; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Denis F; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Pau V; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Mao D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Caldwell L; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Chan K; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, IL, USA., Mamane Y; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Parikh P; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, India., Zhang Z; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Gallant M; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Tyers M; The Hospital for Sick Children Research Institute, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Black WC; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Zinda M; Repare Therapeutics, Suite 1650, Cambridge, MA, USA., Durocher D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wrana J; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. wrana@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. wrana@lunenfeld.ca., Zimmermann M; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada. mchl.zimmermann@gmail.com., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.
Source: Communications chemistry [Commun Chem] 2026 Jun 27. Date of Electronic Publication: 2026 Jun 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem
Database: MEDLINE Ultimate
Description
ISSN:2399-3669
DOI:10.1038/s42004-026-02100-9