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Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

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Title: Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Authors: Mader P; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Liu L; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Vallée F; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Denis F; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Pau V; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Mao D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Caldwell L; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Chan K; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Kurinov I; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, IL, USA., Mamane Y; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Parikh P; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, India., Zhang Z; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Gallant M; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Tyers M; The Hospital for Sick Children Research Institute, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Black WC; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada., Zinda M; Repare Therapeutics, Suite 1650, Cambridge, MA, USA., Durocher D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wrana J; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. wrana@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. wrana@lunenfeld.ca., Zimmermann M; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada. mchl.zimmermann@gmail.com., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.
Source: Communications chemistry [Commun Chem] 2026 Jun 27. Date of Electronic Publication: 2026 Jun 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem
Database: MEDLINE Ultimate
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  Data: Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
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  Data: <searchLink fieldCode="AU" term="%22Mader+P%22">Mader P</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Vallée+F%22">Vallée F</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Denis+F%22">Denis F</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Pau+V%22">Pau V</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Mao+D%22">Mao D</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Caldwell+L%22">Caldwell L</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Chan+K%22">Chan K</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kurinov+I%22">Kurinov I</searchLink>; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mamane+Y%22">Mamane Y</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Parikh+P%22">Parikh P</searchLink>; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Ahmedabad, India.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gallant+M%22">Gallant M</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; The Hospital for Sick Children Research Institute, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Black+WC%22">Black WC</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Zinda+M%22">Zinda M</searchLink>; Repare Therapeutics, Suite 1650, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Durocher+D%22">Durocher D</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Wrana+J%22">Wrana J</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. wrana@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. wrana@lunenfeld.ca.<br /><searchLink fieldCode="AU" term="%22Zimmermann+M%22">Zimmermann M</searchLink>; Repare Therapeutics, 7171 Frederick-Banting, Montréal, QC, Canada. mchl.zimmermann@gmail.com.<br /><searchLink fieldCode="AU" term="%22Sicheri+F%22">Sicheri F</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. sicheri@lunenfeld.ca.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101725670 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2399-3669 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223993669%22">23993669 </searchLink><i>NLM ISO Abbreviation: </i>Commun Chem
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        Value: 10.1038/s42004-026-02100-9
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              Text: 2026 Jun 27
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