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Standardization of objectives and response criteria for neoadjuvant immunotherapy in resectable squamous cell carcinoma of the head and neck.

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Title: Standardization of objectives and response criteria for neoadjuvant immunotherapy in resectable squamous cell carcinoma of the head and neck.
Authors: Resteghini C; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. Electronic address: carlo.resteghini@hunimed.eu., Argiris A; Department of Medical Oncology, Hygeia Hospital, Athens, Greece; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA., Blanchard P; Département de radiothérapie, institut Gustave-Roussy, 114, Rue Édouard-Vaillant, 94805 Villejuif, France., Braña I; Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain., Camarda AM; Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy., Chan ATC; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy, Pavia, Italy., Ferris R; State Key Laboratory in Translational Oncology, Hong Kong Cancer Institute, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region of China., Gregoire V; UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA., Harrington KJ; Centre Léon Bérard, Radiation Oncology, Lyon, France; Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK., Tinhofer I; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK; Department of Radiooncology and Radiotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany., Koljenović S; Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany; Department of Pathology, Antwerp University Hospital, Antwerp, Belgium., Lee NY; Center for Oncological Research (CORE), University of Antwerp, Wilrijk, Antwerp, Belgium., Leemans CR; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Machiels JP; Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Cancer Center Amsterdam, the Netherlands; Pôle oncologie, Institut de Recherche Clinique et Expérimentale, Université catholique de Louvain (UC Louvain), Avenue Hippocrate 10, 1200 Brussels, Belgium., Mehanna H; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Brussels, Belgium., Metcalf R; Institute of Head & Neck Studies and Education (InHANSE), University of Birmingham, Birmingham, UK; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK., O'Sullivan B; The Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK., Oosting S; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada., Orlandi E; Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Paleri V; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, United Kingdom., Psyrri A; Oncology Department, 2nd Propaedeutic Clinic of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Saba NF; Department of Hematology and Medical Oncology, the Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA., Schmitz S; Department of Head and Neck Surgery and Oncology, IRA II, Cliniques Universitaires Saint-Luc, avenue Hippocrate 10, 1200 Brussels., Simon C; Department of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland., Tahara M; Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Poorten VV; University Hospitals Leuven, Department of Oncology, section Head and Neck Oncology, KU Leuven, Belgium., Vošmik M; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic., Bossi P; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Source: Cancer treatment reviews [Cancer Treat Rev] 2026 Jul; Vol. 148, pp. 103175. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1967 (Electronic) Linking ISSN: 03057372 NLM ISO Abbreviation: Cancer Treat Rev Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Standardization of objectives and response criteria for neoadjuvant immunotherapy in resectable squamous cell carcinoma of the head and neck.
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  Data: <searchLink fieldCode="AU" term="%22Resteghini+C%22">Resteghini C</searchLink>; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. Electronic address: carlo.resteghini@hunimed.eu.<br /><searchLink fieldCode="AU" term="%22Argiris+A%22">Argiris A</searchLink>; Department of Medical Oncology, Hygeia Hospital, Athens, Greece; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Blanchard+P%22">Blanchard P</searchLink>; Département de radiothérapie, institut Gustave-Roussy, 114, Rue Édouard-Vaillant, 94805 Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Braña+I%22">Braña I</searchLink>; Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Camarda+AM%22">Camarda AM</searchLink>; Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Chan+ATC%22">Chan ATC</searchLink>; Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferris+R%22">Ferris R</searchLink>; State Key Laboratory in Translational Oncology, Hong Kong Cancer Institute, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Gregoire+V%22">Gregoire V</searchLink>; UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.<br /><searchLink fieldCode="AU" term="%22Harrington+KJ%22">Harrington KJ</searchLink>; Centre Léon Bérard, Radiation Oncology, Lyon, France; Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Tinhofer+I%22">Tinhofer I</searchLink>; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK; Department of Radiooncology and Radiotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Koljenović+S%22">Koljenović S</searchLink>; Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany; Department of Pathology, Antwerp University Hospital, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Lee+NY%22">Lee NY</searchLink>; Center for Oncological Research (CORE), University of Antwerp, Wilrijk, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Leemans+CR%22">Leemans CR</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Machiels+JP%22">Machiels JP</searchLink>; Amsterdam UMC, Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Cancer Center Amsterdam, the Netherlands; Pôle oncologie, Institut de Recherche Clinique et Expérimentale, Université catholique de Louvain (UC Louvain), Avenue Hippocrate 10, 1200 Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Mehanna+H%22">Mehanna H</searchLink>; Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Metcalf+R%22">Metcalf R</searchLink>; Institute of Head & Neck Studies and Education (InHANSE), University of Birmingham, Birmingham, UK; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+B%22">O'Sullivan B</searchLink>; The Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Oosting+S%22">Oosting S</searchLink>; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Orlandi+E%22">Orlandi E</searchLink>; Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Paleri+V%22">Paleri V</searchLink>; The Royal Marsden NHS Foundation Trust, London SW3 6JJ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Psyrri+A%22">Psyrri A</searchLink>; Oncology Department, 2nd Propaedeutic Clinic of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Saba+NF%22">Saba NF</searchLink>; Department of Hematology and Medical Oncology, the Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Schmitz+S%22">Schmitz S</searchLink>; Department of Head and Neck Surgery and Oncology, IRA II, Cliniques Universitaires Saint-Luc, avenue Hippocrate 10, 1200 Brussels.<br /><searchLink fieldCode="AU" term="%22Simon+C%22">Simon C</searchLink>; Department of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tahara+M%22">Tahara M</searchLink>; Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Poorten+VV%22">Poorten VV</searchLink>; University Hospitals Leuven, Department of Oncology, section Head and Neck Oncology, KU Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vošmik+M%22">Vošmik M</searchLink>; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Bossi+P%22">Bossi P</searchLink>; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
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