Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.

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Bibliographic Details
Title: Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.
Authors: Tang H; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Liao Y; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Yeh TY; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Nishibayashi K; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Rouhimoghadam M; Technology & Therapeutic Platforms, AbbVie Incorporated, North Chicago, Illinois 60064, United States., Yang K; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States., Li C; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., de Gonzalez RS; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Zhao Y; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Hawkins NJ; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Reitsma JM; Technology & Therapeutic Platforms, AbbVie Incorporated, North Chicago, Illinois 60064, United States., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States., Tang W; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 09; Vol. 69 (13), pp. 15317-15338. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.6c00020