View in EDS

Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.

Saved in:
Bibliographic Details
Title: Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.
Authors: Tang H; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Liao Y; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Yeh TY; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Nishibayashi K; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Rouhimoghadam M; Technology & Therapeutic Platforms, AbbVie Incorporated, North Chicago, Illinois 60064, United States., Yang K; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States., Li C; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., de Gonzalez RS; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Zhao Y; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Hawkins NJ; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States., Reitsma JM; Technology & Therapeutic Platforms, AbbVie Incorporated, North Chicago, Illinois 60064, United States., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States., Tang W; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 09; Vol. 69 (13), pp. 15317-15338. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42367045
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.<br /><searchLink fieldCode="AU" term="%22Liao+Y%22">Liao Y</searchLink>; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.<br /><searchLink fieldCode="AU" term="%22Yeh+TY%22">Yeh TY</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.<br /><searchLink fieldCode="AU" term="%22Nishibayashi+K%22">Nishibayashi K</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.<br /><searchLink fieldCode="AU" term="%22Rouhimoghadam+M%22">Rouhimoghadam M</searchLink>; Technology & Therapeutic Platforms, AbbVie Incorporated, North Chicago, Illinois 60064, United States.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.<br /><searchLink fieldCode="AU" term="%22de+Gonzalez+RS%22">de Gonzalez RS</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.<br /><searchLink fieldCode="AU" term="%22Hawkins+NJ%22">Hawkins NJ</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.<br /><searchLink fieldCode="AU" term="%22Reitsma+JM%22">Reitsma JM</searchLink>; Technology & Therapeutic Platforms, AbbVie Incorporated, North Chicago, Illinois 60064, United States.<br /><searchLink fieldCode="AU" term="%22Gygi+SP%22">Gygi SP</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jul 09; Vol. 69 (13), pp. 15317-15338. <i>Date of Electronic Publication: </i>2026 Jun 29.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42367045
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.6c00020
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 15317
    Titles:
      – TitleFull: Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tang H
      – PersonEntity:
          Name:
            NameFull: Liao Y
      – PersonEntity:
          Name:
            NameFull: Yeh TY
      – PersonEntity:
          Name:
            NameFull: Nishibayashi K
      – PersonEntity:
          Name:
            NameFull: Rouhimoghadam M
      – PersonEntity:
          Name:
            NameFull: Yang K
      – PersonEntity:
          Name:
            NameFull: Li C
      – PersonEntity:
          Name:
            NameFull: de Gonzalez RS
      – PersonEntity:
          Name:
            NameFull: Zhao Y
      – PersonEntity:
          Name:
            NameFull: Hawkins NJ
      – PersonEntity:
          Name:
            NameFull: Reitsma JM
      – PersonEntity:
          Name:
            NameFull: Gygi SP
      – PersonEntity:
          Name:
            NameFull: Tang W
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 07
              Text: 2026 Jul 09
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 69
            – Type: issue
              Value: 13
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1