Dibutyl phthalate induces sarcopenia via TNFα/TNFR1-mediated proteolytic and pyroptotic axes: evidence from NHANES and experimental models.

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Title: Dibutyl phthalate induces sarcopenia via TNFα/TNFR1-mediated proteolytic and pyroptotic axes: evidence from NHANES and experimental models.
Authors: Yi X; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.; Center for Biobased Materials, Muyuan Laboratory, Zhengzhou, Henan, China.; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China., Li J; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Long X; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Hu X; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Yi L; Department of Encephalopathy (Department of Neurology), Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan, China., Liu L; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Lu X; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Xu T; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Chen Y; School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Zheng HF; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Suzhou Laboratory of Precision Health and Data Science, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China., Ruan H; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Tao J; Center for Biobased Materials, Muyuan Laboratory, Zhengzhou, Henan, China.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Source: Frontiers in immunology [Front Immunol] 2026 Jun 12; Vol. 17, pp. 1853039. Date of Electronic Publication: 2026 Jun 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1853039