Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.

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Title: Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.
Authors: Basu B; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Liu H; Department of Neuroscience and Physiology, College of Graduate Studies, Upstate Medical University, Syracuse, NY., Pandey S; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Obeid H; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Flannery B; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Chen Y; Protein Biophysics and Structure Biology Core Facility, Case Western Reserve University, Cleveland, OH, USA., Yun Y; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Qian A; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Parfyonov D; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Zhao Q; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808 USA., Liu H; Center for Molecular Psychiatry, University of South Florida, Morsani College of Medicine Tampa, FL, USA., Meng J; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Naveh G; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Hanumanthu S; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Hoffman J; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Silva ES; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Leverenz J; Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA., Bekris LM; Genomic Medicine Institute Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Keene CD; Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA., Bournat JC; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., He Y; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808 USA., Mishra I; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Pieper AA; Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center; Cleveland, OH, 44106, USA.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University; Cleveland, OH, 44106, USA.; Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Xu Y; Center for Molecular Psychiatry, University of South Florida, Morsani College of Medicine Tampa, FL, USA., Chopra AR; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University; Cleveland, OH, 44106, USA.; Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Source: Research square [Res Sq] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-9972826/v1