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Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.

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Title: Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.
Authors: Basu B; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Liu H; Department of Neuroscience and Physiology, College of Graduate Studies, Upstate Medical University, Syracuse, NY., Pandey S; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Obeid H; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Flannery B; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Chen Y; Protein Biophysics and Structure Biology Core Facility, Case Western Reserve University, Cleveland, OH, USA., Yun Y; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Qian A; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Parfyonov D; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Zhao Q; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808 USA., Liu H; Center for Molecular Psychiatry, University of South Florida, Morsani College of Medicine Tampa, FL, USA., Meng J; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Naveh G; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Hanumanthu S; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Hoffman J; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Silva ES; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Leverenz J; Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA., Bekris LM; Genomic Medicine Institute Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Keene CD; Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA., Bournat JC; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., He Y; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808 USA., Mishra I; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Pieper AA; Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center; Cleveland, OH, 44106, USA.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University; Cleveland, OH, 44106, USA.; Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Xu Y; Center for Molecular Psychiatry, University of South Florida, Morsani College of Medicine Tampa, FL, USA., Chopra AR; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University; Cleveland, OH, 44106, USA.; Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Source: Research square [Res Sq] 2026 Jun 17. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Asprosin-PTPRD endocrine resistance links brain dysfunction and systemic wasting in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Basu+B%22">Basu B</searchLink>; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Neuroscience and Physiology, College of Graduate Studies, Upstate Medical University, Syracuse, NY.<br /><searchLink fieldCode="AU" term="%22Pandey+S%22">Pandey S</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Obeid+H%22">Obeid H</searchLink>; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Flannery+B%22">Flannery B</searchLink>; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Protein Biophysics and Structure Biology Core Facility, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Yun+Y%22">Yun Y</searchLink>; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Qian+A%22">Qian A</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Parfyonov+D%22">Parfyonov D</searchLink>; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808 USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Center for Molecular Psychiatry, University of South Florida, Morsani College of Medicine Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Meng+J%22">Meng J</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Naveh+G%22">Naveh G</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hanumanthu+S%22">Hanumanthu S</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+J%22">Hoffman J</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Silva+ES%22">Silva ES</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Leverenz+J%22">Leverenz J</searchLink>; Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Bekris+LM%22">Bekris LM</searchLink>; Genomic Medicine Institute Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Keene+CD%22">Keene CD</searchLink>; Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bournat+JC%22">Bournat JC</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, 70808 USA.<br /><searchLink fieldCode="AU" term="%22Mishra+I%22">Mishra I</searchLink>; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Pieper+AA%22">Pieper AA</searchLink>; Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center; Cleveland, OH, 44106, USA.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University; Cleveland, OH, 44106, USA.; Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Center for Molecular Psychiatry, University of South Florida, Morsani College of Medicine Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Chopra+AR%22">Chopra AR</searchLink>; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University; Cleveland, OH, 44106, USA.; Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
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