Targeting homologous recombination deficiency with intensified chemotherapy versus standard chemotherapy followed by olaparib in stage III breast cancer (SUBITO): an open-label, randomised, controlled, phase 3 trial.

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Title: Targeting homologous recombination deficiency with intensified chemotherapy versus standard chemotherapy followed by olaparib in stage III breast cancer (SUBITO): an open-label, randomised, controlled, phase 3 trial.
Authors: Seefat RL; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands., Vliek SB; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, Netherlands., de Jong VMT; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands., Balduzzi S; Department of Biometrics, Netherlands Cancer Institute, Amsterdam, Netherlands., Mandjes IA; Department of Biometrics, Netherlands Cancer Institute, Amsterdam, Netherlands., Retèl VP; Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, Netherlands., Eekhout I; Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, Netherlands., Delfos M; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands., Schot M; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands., Holtkamp MJ; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands., van Rosmalen MM; Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands., Leeneman B; Department of Health Technology Assessment, Erasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, Netherlands., Blommestein H; Department of Health Technology Assessment, Erasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, Netherlands., Huitema ADR; Department of Pharmacy and Pharmacology, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Princess Máxima Centre for Paediatric Oncology, Utrecht, Netherlands., Rosenberg EH; Department of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands., Nederlof PM; Department of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands., Chan TWS; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands., van Rhenen A; Department of Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Wondergem MJ; Department of Haematology, Amsterdam University Medical Center, Amsterdam, Netherlands., Schaap NPM; Department of Haematology, Radboud University Medical Centre, Nijmegen, Netherlands., Snijders TJF; Department of Haematology, Medisch Spectrum Twente, Enschede, Netherlands., Van der Poel MWM; Department of Haematology, Maastricht University Medical Center, Maastricht, Netherlands., Plattel WJ; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., van Werkhoven E; Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands., van Tinteren H; Princess Máxima Centre for Paediatric Oncology, Utrecht, Netherlands., Smidt ML; Department of Surgery, Maastricht University Medical Center, Maastricht, Netherlands., Wesseling J; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands., Jonkers J; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands., Rottenberg S; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Switzerland., Vrancken Peeters MTFD; Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands., Voermans C; Department of Haematology, Amsterdam University Medical Center, Amsterdam, Netherlands; Department of Research, Sanquin Blood Supply Foundation, Amsterdam, Netherlands; Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands., Maduro JH; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Kroep JR; Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands., Schroder CP; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands., Kuip EJM; Department of Medical Oncology, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands., Gonçalves A; Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France., Nuver J; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Wymenga ANM; Department of Medical Oncology, Medisch Spectrum Twente, Enschede, Netherlands., Bijlsma RM; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, Netherlands., van der Wall E; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, Netherlands., Konings IRHM; Department of Medical Oncology, Amsterdam University Medical Center, Amsterdam, Netherlands., Tjan-Heijnen VCG; Department of Medical Oncology, Maastricht University Medical Center, Maastricht, Netherlands., Jongen-Lavrencic M; Department of Haematology, Erasmus University Medical Center, Rotterdam, Netherlands., Jager A; Department of Medical Oncology, Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands., Linn SC; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. Electronic address: s.linn@nki.nl.
Source: The Lancet. Oncology [Lancet Oncol] 2026 Jul; Vol. 27 (7), pp. 795-807.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Comparative Study
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-5488
DOI:10.1016/S1470-2045(26)00131-2