Perioperative systemic therapy versus surgery alone for resectable colorectal peritoneal-only metastases (CAIRO6): a randomised, open-label, phase 3 trial.
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| Title: | Perioperative systemic therapy versus surgery alone for resectable colorectal peritoneal-only metastases (CAIRO6): a randomised, open-label, phase 3 trial. |
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| Authors: | Rovers KP; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands. Electronic address: koen.rovers@catharinaziekenhuis.nlor., Bakkers C; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands., van den Heuvel TBM; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands., van de Vlasakker VCJ; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands., Kerkhoff TME; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands., Nienhuijs SW; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands., Burger JWA; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands., Creemers GM; Department of Medical Oncology, Catharina Cancer Institute, Eindhoven, Netherlands., van Hellemond IEG; Department of Medical Oncology, Catharina Cancer Institute, Eindhoven, Netherlands., Tuynman JB; Department of Surgery, Amsterdam UMC, Amsterdam, Netherlands., Kusters M; Department of Surgery, Amsterdam UMC, Amsterdam, Netherlands., Buffart TE; Department of Medical Oncology, Amsterdam UMC, Amsterdam, Netherlands., Aalbers AGJ; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands., Kok NFM; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands., Chalabi M; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands., Boerma D; Department of Surgery, Sint Antonius Hospital, Nieuwegein, Netherlands., Brandt-Kerkhof ARM; Department of Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands., de Reuver PR; Department of Surgery, Radboud University Medical Centre, Nijmegen, Netherlands., Hemmer PHJ; Department of Surgery, University Medical Centre Groningen, Groningen, Netherlands., van Grevenstein WMU; Department of Surgery, University Medical Centre Utrecht, Utrecht, Netherlands., van der Speeten K; Department of Surgery, Hospital Oost-Limburg, Genk, Belgium; Department of Life Sciences, BIOMED Research Institute, University Hasselt, Diepenbeek, Belgium., Snaebjornsson P; Department of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Lee-Law PY; Department of Pathology, Catharina Cancer Institute, Eindhoven, Netherlands., Lahaye MJ; Department of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands; GROW-Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands., Nederend J; Department of Radiology, Catharina Cancer Institute, Eindhoven, Netherlands., Kranenburg O; Utrecht Platform for Organoid Technology, University Medical Centre Utrecht, Utrecht, Netherlands., Bouma JM; Clinical Trials Office, Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands., Punt CJA; Department of Epidemiology, Julius Centre for Health Sciences and Primary Care, Utrecht, Netherlands., Dijkgraaf MGW; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands., Tanis PJ; Department of Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands., de Hingh IHJT; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands; GROW-Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands. Electronic address: ignace.d.hingh@catharinaziekenhuis.nl. |
| Corporate Authors: | CAIRO6 Investigators, Dutch Peritoneal Oncology Group and the Dutch Colorectal Cancer Group |
| Source: | The Lancet. Oncology [Lancet Oncol] 2026 Jul; Vol. 27 (7), pp. 849-863. |
| Publication Type: | Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Comparative Study |
| Journal Info: | Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42372745 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Perioperative systemic therapy versus surgery alone for resectable colorectal peritoneal-only metastases (CAIRO6): a randomised, open-label, phase 3 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Rovers+KP%22">Rovers KP</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands. Electronic address: koen.rovers@catharinaziekenhuis.nlor.<br /><searchLink fieldCode="AU" term="%22Bakkers+C%22">Bakkers C</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Heuvel+TBM%22">van den Heuvel TBM</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Vlasakker+VCJ%22">van de Vlasakker VCJ</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kerkhoff+TME%22">Kerkhoff TME</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Nienhuijs+SW%22">Nienhuijs SW</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Burger+JWA%22">Burger JWA</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Creemers+GM%22">Creemers GM</searchLink>; Department of Medical Oncology, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Hellemond+IEG%22">van Hellemond IEG</searchLink>; Department of Medical Oncology, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tuynman+JB%22">Tuynman JB</searchLink>; Department of Surgery, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kusters+M%22">Kusters M</searchLink>; Department of Surgery, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Buffart+TE%22">Buffart TE</searchLink>; Department of Medical Oncology, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Aalbers+AGJ%22">Aalbers AGJ</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kok+NFM%22">Kok NFM</searchLink>; Department of Surgery, Netherlands Cancer Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Chalabi+M%22">Chalabi M</searchLink>; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Boerma+D%22">Boerma D</searchLink>; Department of Surgery, Sint Antonius Hospital, Nieuwegein, Netherlands.<br /><searchLink fieldCode="AU" term="%22Brandt-Kerkhof+ARM%22">Brandt-Kerkhof ARM</searchLink>; Department of Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Reuver+PR%22">de Reuver PR</searchLink>; Department of Surgery, Radboud University Medical Centre, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Hemmer+PHJ%22">Hemmer PHJ</searchLink>; Department of Surgery, University Medical Centre Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Grevenstein+WMU%22">van Grevenstein WMU</searchLink>; Department of Surgery, University Medical Centre Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Speeten+K%22">van der Speeten K</searchLink>; Department of Surgery, Hospital Oost-Limburg, Genk, Belgium; Department of Life Sciences, BIOMED Research Institute, University Hasselt, Diepenbeek, Belgium.<br /><searchLink fieldCode="AU" term="%22Snaebjornsson+P%22">Snaebjornsson P</searchLink>; Department of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Lee-Law+PY%22">Lee-Law PY</searchLink>; Department of Pathology, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Lahaye+MJ%22">Lahaye MJ</searchLink>; Department of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands; GROW-Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Nederend+J%22">Nederend J</searchLink>; Department of Radiology, Catharina Cancer Institute, Eindhoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kranenburg+O%22">Kranenburg O</searchLink>; Utrecht Platform for Organoid Technology, University Medical Centre Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bouma+JM%22">Bouma JM</searchLink>; Clinical Trials Office, Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Punt+CJA%22">Punt CJA</searchLink>; Department of Epidemiology, Julius Centre for Health Sciences and Primary Care, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Dijkgraaf+MGW%22">Dijkgraaf MGW</searchLink>; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tanis+PJ%22">Tanis PJ</searchLink>; Department of Surgery, Erasmus University Medical Centre, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Hingh+IHJT%22">de Hingh IHJT</searchLink>; Department of Surgery, Catharina Cancer Institute, Eindhoven, Netherlands; GROW-Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands. Electronic address: ignace.d.hingh@catharinaziekenhuis.nl. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22CAIRO6+Investigators%22">CAIRO6 Investigators</searchLink><br /><searchLink fieldCode="CA" term="%22Dutch+Peritoneal+Oncology+Group+and+the+Dutch+Colorectal+Cancer+Group%22">Dutch Peritoneal Oncology Group and the Dutch Colorectal Cancer Group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2026 Jul; Vol. 27 (7), pp. 849-863. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42372745 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S1470-2045(26)00085-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 849 Titles: – TitleFull: Perioperative systemic therapy versus surgery alone for resectable colorectal peritoneal-only metastases (CAIRO6): a randomised, open-label, phase 3 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rovers KP – PersonEntity: Name: NameFull: Bakkers C – PersonEntity: Name: NameFull: van den Heuvel TBM – PersonEntity: Name: NameFull: van de Vlasakker VCJ – PersonEntity: Name: NameFull: Kerkhoff TME – PersonEntity: Name: NameFull: Nienhuijs SW – PersonEntity: Name: NameFull: Burger JWA – PersonEntity: Name: NameFull: Creemers GM – PersonEntity: Name: NameFull: van Hellemond IEG – PersonEntity: Name: NameFull: Tuynman JB – PersonEntity: Name: NameFull: Kusters M – PersonEntity: Name: NameFull: Buffart TE – PersonEntity: Name: NameFull: Aalbers AGJ – PersonEntity: Name: NameFull: Kok NFM – PersonEntity: Name: NameFull: Chalabi M – PersonEntity: Name: NameFull: Boerma D – PersonEntity: Name: NameFull: Brandt-Kerkhof ARM – PersonEntity: Name: NameFull: de Reuver PR – PersonEntity: Name: NameFull: Hemmer PHJ – PersonEntity: Name: NameFull: van Grevenstein WMU – PersonEntity: Name: NameFull: van der Speeten K – PersonEntity: Name: NameFull: Snaebjornsson P – PersonEntity: Name: NameFull: Lee-Law PY – PersonEntity: Name: NameFull: Lahaye MJ – PersonEntity: Name: NameFull: Nederend J – PersonEntity: Name: NameFull: Kranenburg O – PersonEntity: Name: NameFull: Bouma JM – PersonEntity: Name: NameFull: Punt CJA – PersonEntity: Name: NameFull: Dijkgraaf MGW – PersonEntity: Name: NameFull: Tanis PJ – PersonEntity: Name: NameFull: de Hingh IHJT IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1474-5488 Numbering: – Type: volume Value: 27 – Type: issue Value: 7 Titles: – TitleFull: The Lancet. Oncology Type: main |
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