Small Molecule Stabilization of Diverse Amyloidogenic Immunoglobulin Light Chains Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.

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Title: Small Molecule Stabilization of Diverse Amyloidogenic Immunoglobulin Light Chains Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.
Authors: Peterle D; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA. Electronic address: daniele@peptone.io., Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Klimtchuk ES; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Srinivasu BY; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Brusic V; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Rhoades D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Wales TE; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Gursky O; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Engen JR; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Morgan GJ; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Section of Hematology and Medical Oncology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: gjmorgan@bu.edu.
Source: Journal of molecular biology [J Mol Biol] 2026 Jun 29; Vol. 438 (19), pp. 169917. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1089-8638
DOI:10.1016/j.jmb.2026.169917