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Small Molecule Stabilization of Diverse Amyloidogenic Immunoglobulin Light Chains Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.

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Title: Small Molecule Stabilization of Diverse Amyloidogenic Immunoglobulin Light Chains Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.
Authors: Peterle D; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA. Electronic address: daniele@peptone.io., Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Klimtchuk ES; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Srinivasu BY; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Brusic V; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Rhoades D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Wales TE; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Gursky O; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Engen JR; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA., Morgan GJ; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Section of Hematology and Medical Oncology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: gjmorgan@bu.edu.
Source: Journal of molecular biology [J Mol Biol] 2026 Jun 29; Vol. 438 (19), pp. 169917. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Peterle+D%22">Peterle D</searchLink>; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA. Electronic address: daniele@peptone.io.<br /><searchLink fieldCode="AU" term="%22Yan+NL%22">Yan NL</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Klimtchuk+ES%22">Klimtchuk ES</searchLink>; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Srinivasu+BY%22">Srinivasu BY</searchLink>; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brusic+V%22">Brusic V</searchLink>; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rhoades+D%22">Rhoades D</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wales+TE%22">Wales TE</searchLink>; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gursky+O%22">Gursky O</searchLink>; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+JW%22">Kelly JW</searchLink>; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Engen+JR%22">Engen JR</searchLink>; Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+GJ%22">Morgan GJ</searchLink>; Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Section of Hematology and Medical Oncology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: gjmorgan@bu.edu.
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  Data: <searchLink fieldCode="JN" term="%222985088R%22">Journal of molecular biology</searchLink> [J Mol Biol] 2026 Jun 29; Vol. 438 (19), pp. 169917. <i>Date of Electronic Publication: </i>2026 Jun 29.
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