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Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.

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Title: Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.
Authors: Koopman LA; Genmab (Netherlands) Utrecht Netherlands., Alemdehy F; Genmab (Netherlands) Utrecht Netherlands., de Poot SAH; Genmab (Netherlands) Utrecht Netherlands., Paauwe M; Genmab (Netherlands) Utrecht Netherlands., Wang W; Genmab (Netherlands) Utrecht Netherlands., Epstein KR; University of Pennsylvania Philadelphia United States., van den Brink EN; Genmab (Netherlands) Utrecht Netherlands., Gorlani A; Genmab (Netherlands) Utrecht Netherlands., Verzijl D; Genmab (Netherlands) Utrecht Netherlands., Brandhorst M; Genmab (Netherlands) Utrecht Netherlands., Franken P; Genmab (Netherlands) Utrecht Netherlands., Smits-de Vries L; Genmab (Netherlands) Utrecht Netherlands., Gielen E; Genmab (Netherlands) Utrecht Netherlands., Plantinga TS; Genmab (Netherlands) Utrecht Netherlands., Houtkamp M; Genmab (Netherlands) Utrecht Netherlands., Engelberts PJ; Genmab (Netherlands) Utrecht Netherlands., Lihme Egerod F; Genmab (Denmark) Copenhagen Denmark., Thalhauser CJ; Genmab (United States) Plainsboro, New Jersey United States., Bosgra S; Genmab (Netherlands) Utrecht Netherlands., Gitto SB; University of Pennsylvania Philadelphia, PA United States., Powell DJ; University of Pennsylvania Philadelphia, PA United States., Gamse JT; Genmab (United States) Plainsboro, NJ United States., Overdijk MB; Genmab (Netherlands) Utrecht, utrecht Netherlands., Breij ECW; Genmab (Netherlands) Utrecht Netherlands.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.
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  Data: <searchLink fieldCode="AU" term="%22Koopman+LA%22">Koopman LA</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Alemdehy+F%22">Alemdehy F</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Poot+SAH%22">de Poot SAH</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Paauwe+M%22">Paauwe M</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Epstein+KR%22">Epstein KR</searchLink>; University of Pennsylvania Philadelphia United States.<br /><searchLink fieldCode="AU" term="%22van+den+Brink+EN%22">van den Brink EN</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Gorlani+A%22">Gorlani A</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Verzijl+D%22">Verzijl D</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Brandhorst+M%22">Brandhorst M</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Franken+P%22">Franken P</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Smits-de+Vries+L%22">Smits-de Vries L</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Gielen+E%22">Gielen E</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Plantinga+TS%22">Plantinga TS</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Houtkamp+M%22">Houtkamp M</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Engelberts+PJ%22">Engelberts PJ</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Lihme+Egerod+F%22">Lihme Egerod F</searchLink>; Genmab (Denmark) Copenhagen Denmark.<br /><searchLink fieldCode="AU" term="%22Thalhauser+CJ%22">Thalhauser CJ</searchLink>; Genmab (United States) Plainsboro, New Jersey United States.<br /><searchLink fieldCode="AU" term="%22Bosgra+S%22">Bosgra S</searchLink>; Genmab (Netherlands) Utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Gitto+SB%22">Gitto SB</searchLink>; University of Pennsylvania Philadelphia, PA United States.<br /><searchLink fieldCode="AU" term="%22Powell+DJ%22">Powell DJ</searchLink>; University of Pennsylvania Philadelphia, PA United States.<br /><searchLink fieldCode="AU" term="%22Gamse+JT%22">Gamse JT</searchLink>; Genmab (United States) Plainsboro, NJ United States.<br /><searchLink fieldCode="AU" term="%22Overdijk+MB%22">Overdijk MB</searchLink>; Genmab (Netherlands) Utrecht, utrecht Netherlands.<br /><searchLink fieldCode="AU" term="%22Breij+ECW%22">Breij ECW</searchLink>; Genmab (Netherlands) Utrecht Netherlands.
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        Value: 10.1158/1535-7163.MCT-26-0054
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        Text: English
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      – TitleFull: Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.
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              Text: 2026 Jun 30
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