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Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.

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Title: Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.
Authors: Yang T; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA. Electronic address: tyang@bwh.harvard.edu., Xu YR; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Li S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Bellier JP; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Tao Y; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Francis AE; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Stern AM; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Jin S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Ostaszewski BL; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Lawton TL; Abyssinia Biologics, Inc, 855 Boylston Street, #1000, Boston, MA 02116, USA., Pradier L; Sanofi Neurodegenerative Research, Chilly Mazarin, France., Reczek D; Sanofi US Large Molecule Research, 350 Water St, Cambridge, MA 02141, USA., Lemere CA; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Walsh DM; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Selkoe DJ; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA. Electronic address: dselkoe@bwh.harvard.edu.
Source: Cell reports [Cell Rep] 2026 Jun 30; Vol. 45 (7), pp. 117599. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.
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  Data: <searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA. Electronic address: tyang@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Xu+YR%22">Xu YR</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Bellier+JP%22">Bellier JP</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Francis+AE%22">Francis AE</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Stern+AM%22">Stern AM</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Jin+S%22">Jin S</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Ostaszewski+BL%22">Ostaszewski BL</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lawton+TL%22">Lawton TL</searchLink>; Abyssinia Biologics, Inc, 855 Boylston Street, #1000, Boston, MA 02116, USA.<br /><searchLink fieldCode="AU" term="%22Pradier+L%22">Pradier L</searchLink>; Sanofi Neurodegenerative Research, Chilly Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Reczek+D%22">Reczek D</searchLink>; Sanofi US Large Molecule Research, 350 Water St, Cambridge, MA 02141, USA.<br /><searchLink fieldCode="AU" term="%22Lemere+CA%22">Lemere CA</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+DM%22">Walsh DM</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Selkoe+DJ%22">Selkoe DJ</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA. Electronic address: dselkoe@bwh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jun 30; Vol. 45 (7), pp. 117599. <i>Date of Electronic Publication: </i>2026 Jun 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101573691 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2211-1247 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.celrep.2026.117599
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      – TitleFull: Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.
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