Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.

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Title: Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.
Authors: Lepori I; Department of Microbiology, University of Massachusetts Amherst, Amherst, MA, USA. ilepori@umass.edu., Liu Z; Department of Chemistry, University of Virginia, Charlottesville, VA, USA., Evbarunegbe N; Manning College of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA, USA., Feng S; Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA.; Department of Bioengineering, Lehigh University, Bethlehem, PA, USA.; Merck Research Laboratories, Boston, MA, USA., Brown TP; Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA.; Department of Bioengineering, Lehigh University, Bethlehem, PA, USA., Mane K; Department of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School, Newark, NJ, USA., Dash R; Department of Chemistry, University of Virginia, Charlottesville, VA, USA., Shivangi; Department of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School, Newark, NJ, USA., Wong M; Department of Microbiology, University of Massachusetts Amherst, Amherst, MA, USA., Naick A; Department of Chemistry, University of Virginia, Charlottesville, VA, USA., George A; Department of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School, Newark, NJ, USA., Guo T; Institute of Translational Medicine, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China., Shelke AM; Department of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School, Newark, NJ, USA., Sharpless KB; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Dong J; Institute of Translational Medicine, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China., Freundlich JS; Department of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School, Newark, NJ, USA. freundjs@rutgers.edu., Im W; Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA. wonpil@lehigh.edu.; Department of Bioengineering, Lehigh University, Bethlehem, PA, USA. wonpil@lehigh.edu., Green AG; Manning College of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA, USA. annagreen@umass.edu., Pires MM; Department of Chemistry, University of Virginia, Charlottesville, VA, USA. mp7aa@virginia.edu., Siegrist MS; Department of Microbiology, University of Massachusetts Amherst, Amherst, MA, USA. siegrist@umass.edu.; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA, USA. siegrist@umass.edu.
Source: Nature microbiology [Nat Microbiol] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2058-5276
DOI:10.1038/s41564-026-02412-5