Deep learning-driven integrated pipeline for de novo design and synthesis of antimicrobial peptides.

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Title: Deep learning-driven integrated pipeline for de novo design and synthesis of antimicrobial peptides.
Authors: Liu J; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; Key Laboratory of Bioactive Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China., Chen Y; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; Key Laboratory of Bioactive Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China., Tang J; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; Key Laboratory of Bioactive Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China., Xing X; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; Key Laboratory of Bioactive Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China., Lin JS; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; State Key Laboratory of Chemical Oncogenomics, Tsinghua Shenzhen International Graduate School, Shenzhen, China., Sun J; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; Key Laboratory of Bioactive Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China., Xing XH; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; Key Laboratory of Bioactive Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, China., Li J; Energy and Transportation Domain, Beijing Institute of Technology, Zhuhai, China., Zhang CY; Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China. zhang.cy@sz.tsinghua.edu.cn.; Key Laboratory of Bioactive Proteins and Peptides Green Biomanufacturing of Guangdong Higher Education Institutes, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China. zhang.cy@sz.tsinghua.edu.cn.; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing, China. zhang.cy@sz.tsinghua.edu.cn.
Source: Npj drug discovery [NPJ Drug Discov] 2026 May 04; Vol. 3 (1). Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918993695206676 Publication Model: Electronic Cited Medium: Internet ISSN: 3005-1452 (Electronic) Linking ISSN: 30051452 NLM ISO Abbreviation: NPJ Drug Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:3005-1452
DOI:10.1038/s44386-026-00045-6