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Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

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Title: Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.
Authors: Ananthapadmanabhan V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Bruno S; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA., Vonk L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Cheng YC; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Teshager A; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Eschle BK; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Howarth CL; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA., Rodrigues JS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Schnabel J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Program in Virology, Graduate School of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA., Kodali A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Gokhale PC; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Kshirsagar R; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA., Breitkopf SB; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA., Sharma K; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Li Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Cherniack AD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Michor F; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Ludwig Center at Harvard, Boston, Massachusetts, USA., Chutake Y; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA., Dey J; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA., DeCaprio JA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Program in Virology, Graduate School of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Jul 01; Vol. 136 (13). Date of Electronic Publication: 2026 Jul 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
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  Data: Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.
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  Data: <searchLink fieldCode="AU" term="%22Ananthapadmanabhan+V%22">Ananthapadmanabhan V</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bruno+S%22">Bruno S</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Vonk+L%22">Vonk L</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+YC%22">Cheng YC</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Teshager+A%22">Teshager A</searchLink>; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Eschle+BK%22">Eschle BK</searchLink>; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Howarth+CL%22">Howarth CL</searchLink>; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rodrigues+JS%22">Rodrigues JS</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Schnabel+J%22">Schnabel J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Program in Virology, Graduate School of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kodali+A%22">Kodali A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gokhale+PC%22">Gokhale PC</searchLink>; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kshirsagar+R%22">Kshirsagar R</searchLink>; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Breitkopf+SB%22">Breitkopf SB</searchLink>; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+K%22">Sharma K</searchLink>; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Paulo+JA%22">Paulo JA</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Cherniack+AD%22">Cherniack AD</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Michor+F%22">Michor F</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; The Ludwig Center at Harvard, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chutake+Y%22">Chutake Y</searchLink>; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Dey+J%22">Dey J</searchLink>; Kymera Therapeutics, Inc., 500 North Beacon Street, Watertown, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22DeCaprio+JA%22">DeCaprio JA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Program in Virology, Graduate School of Arts and Sciences, Harvard University, Cambridge, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2026 Jul 01; Vol. 136 (13). <i>Date of Electronic Publication: </i>2026 Jul 01 (<i>Print Publication: </i>2026).
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