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Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.

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Title: Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.
Authors: Shaffer KJ; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand., Gilaj N; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Wagner AG; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Popadynec M; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand., Groom DP; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Hughes LA; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand., Ghosh A; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Paparella A; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Tyler PC; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand., Lamiable-Oulaidi F; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand., Schramm VL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 16722-16747. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Shaffer+KJ%22">Shaffer KJ</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.<br /><searchLink fieldCode="AU" term="%22Gilaj+N%22">Gilaj N</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.<br /><searchLink fieldCode="AU" term="%22Wagner+AG%22">Wagner AG</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.<br /><searchLink fieldCode="AU" term="%22Popadynec+M%22">Popadynec M</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.<br /><searchLink fieldCode="AU" term="%22Groom+DP%22">Groom DP</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.<br /><searchLink fieldCode="AU" term="%22Hughes+LA%22">Hughes LA</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.<br /><searchLink fieldCode="AU" term="%22Ghosh+A%22">Ghosh A</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.<br /><searchLink fieldCode="AU" term="%22Paparella+A%22">Paparella A</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.<br /><searchLink fieldCode="AU" term="%22Tyler+PC%22">Tyler PC</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lamiable-Oulaidi+F%22">Lamiable-Oulaidi F</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand.<br /><searchLink fieldCode="AU" term="%22Schramm+VL%22">Schramm VL</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 16722-16747. <i>Date of Electronic Publication: </i>2026 Jul 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.6c00369
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      – TitleFull: Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.
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              Text: 2026 Jul 23
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