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Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models.

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Title: Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models.
Authors: Shiva N; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Kawase H; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Cardiology, Nagoya University School of Medicine, Nagoya, Japan., Einsiedel J; Department of Chemistry and Pharmacy, Friedrich Alexander University, Erlangen, Germany., Kwon J; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Kumar S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Shao J; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Du Z; Circadian Regulation of Cardiometabolism Lab, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany., Kubin N; Department of Cardiology, Campus Kerckhoff, Bad Nauheim and Medical Clinic I, Justus-Liebig-University Giessen, Giessen, Germany., Shimari M; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Günther S; Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Li T; Department of Biochemistry and Physiology, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Dierickx P; Circadian Regulation of Cardiometabolism Lab, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany., Sossalla S; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Department of Cardiology, Campus Kerckhoff, Bad Nauheim and Medical Clinic I, Justus-Liebig-University Giessen, Giessen, Germany., Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany.; Centre for Molecular Medicine, Medical Faculty, Goethe University, Frankfurt am Main, Germany., Gmeiner P; Department of Chemistry and Pharmacy, Friedrich Alexander University, Erlangen, Germany., Wettschureck N; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany.; Centre for Molecular Medicine, Medical Faculty, Goethe University, Frankfurt am Main, Germany.
Source: Science translational medicine [Sci Transl Med] 2026 Jul; Vol. 18 (856), pp. eaea9877. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models.
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  Data: <searchLink fieldCode="AU" term="%22Shiva+N%22">Shiva N</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Kawase+H%22">Kawase H</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Cardiology, Nagoya University School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Einsiedel+J%22">Einsiedel J</searchLink>; Department of Chemistry and Pharmacy, Friedrich Alexander University, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kwon+J%22">Kwon J</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Shao+J%22">Shao J</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Du+Z%22">Du Z</searchLink>; Circadian Regulation of Cardiometabolism Lab, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Kubin+N%22">Kubin N</searchLink>; Department of Cardiology, Campus Kerckhoff, Bad Nauheim and Medical Clinic I, Justus-Liebig-University Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Shimari+M%22">Shimari M</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Günther+S%22">Günther S</searchLink>; Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Department of Biochemistry and Physiology, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Dierickx+P%22">Dierickx P</searchLink>; Circadian Regulation of Cardiometabolism Lab, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Sossalla+S%22">Sossalla S</searchLink>; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Department of Cardiology, Campus Kerckhoff, Bad Nauheim and Medical Clinic I, Justus-Liebig-University Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Offermanns+S%22">Offermanns S</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany.; Centre for Molecular Medicine, Medical Faculty, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Gmeiner+P%22">Gmeiner P</searchLink>; Department of Chemistry and Pharmacy, Friedrich Alexander University, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wettschureck+N%22">Wettschureck N</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Frankfurt am Main, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt am Main, Germany.; Centre for Molecular Medicine, Medical Faculty, Goethe University, Frankfurt am Main, Germany.
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