Pathophysiology-based subtypes of individuals at high risk of type 2 diabetes: multi-omics profiles and lifestyle differences across subtypes.

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Title: Pathophysiology-based subtypes of individuals at high risk of type 2 diabetes: multi-omics profiles and lifestyle differences across subtypes.
Authors: Deng K; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Hameete A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Schrauwen P; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, 40225, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany., Wagner R; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, 40225, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Moorenstr, Düsseldorf, Germany., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., le Cessie S; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.li@lumc.nl.
Source: Metabolism: clinical and experimental [Metabolism] 2026 Jul 01; Vol. 183, pp. 156687. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-8600
DOI:10.1016/j.metabol.2026.156687