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Pathophysiology-based subtypes of individuals at high risk of type 2 diabetes: multi-omics profiles and lifestyle differences across subtypes.

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Title: Pathophysiology-based subtypes of individuals at high risk of type 2 diabetes: multi-omics profiles and lifestyle differences across subtypes.
Authors: Deng K; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Hameete A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Schrauwen P; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, 40225, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany., Wagner R; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, 40225, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Moorenstr, Düsseldorf, Germany., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., le Cessie S; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.li@lumc.nl.
Source: Metabolism: clinical and experimental [Metabolism] 2026 Jul 01; Vol. 183, pp. 156687. Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Deng+K%22">Deng K</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hameete+A%22">Hameete A</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schrauwen+P%22">Schrauwen P</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, 40225, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+R%22">Wagner R</searchLink>; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, 40225, Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Moorenstr, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22van+Hylckama+Vlieg+A%22">van Hylckama Vlieg A</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rosendaal+FR%22">Rosendaal FR</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mook-Kanamori+DO%22">Mook-Kanamori DO</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22le+Cessie+S%22">le Cessie S</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Dijk+KW%22">van Dijk KW</searchLink>; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Mutsert+R%22">de Mutsert R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Li-Gao+R%22">Li-Gao R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.li@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%220375267%22">Metabolism: clinical and experimental</searchLink> [Metabolism] 2026 Jul 01; Vol. 183, pp. 156687. <i>Date of Electronic Publication: </i>2026 Jul 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0375267 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-8600 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200260495%22">00260495 </searchLink><i>NLM ISO Abbreviation: </i>Metabolism <i>Subsets: </i>MEDLINE
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