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Osimertinib-induced cardiotoxicity is driven by HDAC-dependent epigenetic repression and rescued by vorinostat.

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Title: Osimertinib-induced cardiotoxicity is driven by HDAC-dependent epigenetic repression and rescued by vorinostat.
Authors: Toro Cora A; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Bhati AS; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Titus AS; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Jaiswal A; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Singh B; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Umbarkar P; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Li DY; Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, AL, USA., Dutta R; Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, AL, USA., Zhang Q; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Verma SK; Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, AL, USA., Tousif S; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA., Lal H; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA. Hind.lal@lsuhs.edu.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jul 02; Vol. 11 (1). Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Osimertinib-induced cardiotoxicity is driven by HDAC-dependent epigenetic repression and rescued by vorinostat.
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  Data: <searchLink fieldCode="AU" term="%22Toro+Cora+A%22">Toro Cora A</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Bhati+AS%22">Bhati AS</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Titus+AS%22">Titus AS</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Jaiswal+A%22">Jaiswal A</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Singh+B%22">Singh B</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Umbarkar+P%22">Umbarkar P</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Li+DY%22">Li DY</searchLink>; Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+R%22">Dutta R</searchLink>; Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Verma+SK%22">Verma SK</searchLink>; Division of Cardiovascular Disease, The University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Tousif+S%22">Tousif S</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA.<br /><searchLink fieldCode="AU" term="%22Lal+H%22">Lal H</searchLink>; Department of Cellular Biology & Anatomy, LSU Health Shreveport, Shreveport, LA, USA. Hind.lal@lsuhs.edu.
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  Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2026 Jul 02; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Jul 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41392-026-02814-1
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        Text: English
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              Text: 2026 Jul 02
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