Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis.
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| Title: | Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis. |
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| Authors: | Passmore M; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Jian X; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia., Zhao X; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia., de Los Santos ELC; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK.; UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK., Roberts DM; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Erebagen Ltd, CIE Building, Begbroke Science Park, Oxfordshire, OX5 1PF, UK., Lewandowski JR; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Jenner M; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. M.Jenner@warwick.ac.uk.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. M.Jenner@warwick.ac.uk., Alkhalaf LM; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. L.Alkhalaf.1@warwick.ac.uk., Challis GL; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. G.L.Challis@warwick.ac.uk.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. G.L.Challis@warwick.ac.uk.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. G.L.Challis@warwick.ac.uk.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia. G.L.Challis@warwick.ac.uk. |
| Source: | Nature communications [Nat Commun] 2026 Jul 01; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-74383-4 |
