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Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis.

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Title: Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis.
Authors: Passmore M; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Jian X; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia., Zhao X; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia., de Los Santos ELC; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK.; UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK., Roberts DM; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Erebagen Ltd, CIE Building, Begbroke Science Park, Oxfordshire, OX5 1PF, UK., Lewandowski JR; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Jenner M; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. M.Jenner@warwick.ac.uk.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. M.Jenner@warwick.ac.uk., Alkhalaf LM; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. L.Alkhalaf.1@warwick.ac.uk., Challis GL; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. G.L.Challis@warwick.ac.uk.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. G.L.Challis@warwick.ac.uk.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. G.L.Challis@warwick.ac.uk.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia. G.L.Challis@warwick.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jul 01; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis.
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  Data: <searchLink fieldCode="AU" term="%22Passmore+M%22">Passmore M</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Jian+X%22">Jian X</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22de+Los+Santos+ELC%22">de Los Santos ELC</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK.; UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+DM%22">Roberts DM</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; Erebagen Ltd, CIE Building, Begbroke Science Park, Oxfordshire, OX5 1PF, UK.<br /><searchLink fieldCode="AU" term="%22Lewandowski+JR%22">Lewandowski JR</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.<br /><searchLink fieldCode="AU" term="%22Jenner+M%22">Jenner M</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. M.Jenner@warwick.ac.uk.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. M.Jenner@warwick.ac.uk.<br /><searchLink fieldCode="AU" term="%22Alkhalaf+LM%22">Alkhalaf LM</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. L.Alkhalaf.1@warwick.ac.uk.<br /><searchLink fieldCode="AU" term="%22Challis+GL%22">Challis GL</searchLink>; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. G.L.Challis@warwick.ac.uk.; Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. G.L.Challis@warwick.ac.uk.; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. G.L.Challis@warwick.ac.uk.; ARC Centre of Excellence for Innovations in Protein and Peptide Science, Monash University, Clayton, VIC, Australia. G.L.Challis@warwick.ac.uk.
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              Text: 2026 Jul 01
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