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In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key Fold.

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Title: In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key Fold.
Authors: Milchberg MH; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; Graduate Program in Biophysics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Warmuth OA; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; Graduate Program in Biophysics, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Borcik CG; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Han R; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Harding BD; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., DeZonia B; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Dhavale DD; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Pierson JA; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States., Kotzbauer PT; Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Wright ER; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; Cryo-Electron Microscopy Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; Midwest Center for Cryo-Electron Tomography, Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; Morgridge Institute for Research, Madison, Wisconsin 53715, United States., Schwieters CD; Computational Biomolecular Magnetic Resonance Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Rienstra CM; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.; Morgridge Institute for Research, Madison, Wisconsin 53715, United States.; National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Source: The journal of physical chemistry. B [J Phys Chem B] 2026 Jul 16; Vol. 130 (28), pp. 7120-7133. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5207 (Electronic) Linking ISSN: 15205207 NLM ISO Abbreviation: J Phys Chem B Subsets: MEDLINE
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