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A dietary switch promotes sensory neuron-dependent cancer-associated cachexia.

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Title: A dietary switch promotes sensory neuron-dependent cancer-associated cachexia.
Authors: Cross M; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA., Kotschi S; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Wu W; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Luciano-Mateo F; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Kwon YY; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Dantas E; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Niazi T; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Chen S; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Rashidfarrokhi A; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Pillai R; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, VA New York Harbor Healthcare System, New York, NY, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York, NY, USA., Sanford J; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Kim J; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Hsiang J; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Gamallo-Lana B; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA., Mar AC; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA., Hao Y; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA., Rajalingam S; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Huang A; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Shan J; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Issa HA; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Gomez M; Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.; Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick, NJ, USA.; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA., Wang AR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Medical Scientist Training Program, Stony Brook University School of Medicine, Stony Brook, NY, USA.; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA., Zhao X; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Janowitz T; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Northwell Health, New York, NY, USA., White E; Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.; Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick, NJ, USA.; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA., Liu Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Wong KK; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Segal LN; Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York, NY, USA., Hui S; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Goncalves MD; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Froemke RC; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Papagiannakopoulos T; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jul 02; Vol. 393 (6806), pp. 90-97. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.adz4196