A dietary switch promotes sensory neuron-dependent cancer-associated cachexia.

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Title: A dietary switch promotes sensory neuron-dependent cancer-associated cachexia.
Authors: Cross M; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA., Kotschi S; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Wu W; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Luciano-Mateo F; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Kwon YY; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Dantas E; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Niazi T; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Chen S; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Rashidfarrokhi A; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Pillai R; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, VA New York Harbor Healthcare System, New York, NY, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York, NY, USA., Sanford J; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Kim J; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Hsiang J; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Gamallo-Lana B; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA., Mar AC; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA., Hao Y; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA., Rajalingam S; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Huang A; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Shan J; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Issa HA; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Gomez M; Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.; Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick, NJ, USA.; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA., Wang AR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Medical Scientist Training Program, Stony Brook University School of Medicine, Stony Brook, NY, USA.; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA., Zhao X; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Janowitz T; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Northwell Health, New York, NY, USA., White E; Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.; Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick, NJ, USA.; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA., Liu Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Wong KK; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., Segal LN; Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York, NY, USA., Hui S; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Goncalves MD; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Froemke RC; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA., Papagiannakopoulos T; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jul 02; Vol. 393 (6806), pp. 90-97. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: A dietary switch promotes sensory neuron-dependent cancer-associated cachexia.
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Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dantas+E%22">Dantas E</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Niazi+T%22">Niazi T</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rashidfarrokhi+A%22">Rashidfarrokhi A</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pillai+R%22">Pillai R</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, VA New York Harbor Healthcare System, New York, NY, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sanford+J%22">Sanford J</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hsiang+J%22">Hsiang J</searchLink>; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gamallo-Lana+B%22">Gamallo-Lana B</searchLink>; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mar+AC%22">Mar AC</searchLink>; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hao+Y%22">Hao Y</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rajalingam+S%22">Rajalingam S</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Huang+A%22">Huang A</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shan+J%22">Shan J</searchLink>; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Issa+HA%22">Issa HA</searchLink>; Department of Neuroscience, New York University Grossman School of Medicine, New York, NY, USA.; Translational Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Center for Neural Science, New York University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gomez+M%22">Gomez M</searchLink>; Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.; Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick, NJ, USA.; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wang+AR%22">Wang AR</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Medical Scientist Training Program, Stony Brook University School of Medicine, Stony Brook, NY, USA.; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Janowitz+T%22">Janowitz T</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Northwell Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22White+E%22">White E</searchLink>; Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.; Department of Molecular Biology and Biochemistry, Rutgers University, New Brunswick, NJ, USA.; Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.<br /><searchLink fieldCode="AU" term="%22Wong+KK%22">Wong KK</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Segal+LN%22">Segal LN</searchLink>; Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hui+S%22">Hui S</searchLink>; Department of Molecular Metabolism, Harvard T.H. 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