Membrane protein solubilization and structure determination using de novo-designed proteins.
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| Title: | Membrane protein solubilization and structure determination using de novo-designed proteins. |
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| Authors: | Mihaljević L; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Kim DE; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Bandawane PD; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Eisenach HE; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Borst AJ; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Courbet A; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Centre de Biologie Structurale, University of Montpellier, CNRS, INSERM. Montpellier, France., Weidle C; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Carr KD; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Bettin E; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA., Liu Q; Kymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK., Trejos AT; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Majumder S; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Kokane S; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Stevens A; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Muratspahić E; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Schlichthaerle T; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Expòsit M; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Li X; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Lamb M; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Azcárraga Murray AN; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Ravichandran R; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Williams EC; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Hu S; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Stuart L; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Grillová L; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK., Thomson NR; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Landreh M; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden., Chang P; Kymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK., Giacani L; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Caimano MJ; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA., Hawley KL; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Division of Infectious Diseases and Immunology, Connecticut Children's, Hartford CT, USA.; Department of Research, Connecticut Children's Research Institute, Hartford CT, USA., King NP; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Baker D; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. |
| Source: | Science (New York, N.Y.) [Science] 2026 Jul 02; Vol. 393 (6806), pp. eadr3817. Date of Electronic Publication: 2026 Jul 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adr3817 |
