View in EDS HTML Full Text PDF Full Text

Membrane protein solubilization and structure determination using de novo-designed proteins.

Saved in:
Bibliographic Details
Title: Membrane protein solubilization and structure determination using de novo-designed proteins.
Authors: Mihaljević L; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Kim DE; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Bandawane PD; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Eisenach HE; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Borst AJ; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Courbet A; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Centre de Biologie Structurale, University of Montpellier, CNRS, INSERM. Montpellier, France., Weidle C; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Carr KD; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Bettin E; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA., Liu Q; Kymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK., Trejos AT; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Majumder S; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Kokane S; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Stevens A; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Muratspahić E; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Schlichthaerle T; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Expòsit M; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Li X; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Lamb M; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Azcárraga Murray AN; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Ravichandran R; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Williams EC; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Hu S; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Stuart L; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Grillová L; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK., Thomson NR; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Landreh M; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden., Chang P; Kymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK., Giacani L; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Caimano MJ; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA., Hawley KL; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Division of Infectious Diseases and Immunology, Connecticut Children's, Hartford CT, USA.; Department of Research, Connecticut Children's Research Institute, Hartford CT, USA., King NP; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Baker D; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jul 02; Vol. 393 (6806), pp. eadr3817. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42391386
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Membrane protein solubilization and structure determination using de novo-designed proteins.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Mihaljević+L%22">Mihaljević L</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+DE%22">Kim DE</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bandawane+PD%22">Bandawane PD</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Eisenach+HE%22">Eisenach HE</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Borst+AJ%22">Borst AJ</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Courbet+A%22">Courbet A</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Centre de Biologie Structurale, University of Montpellier, CNRS, INSERM. Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Weidle+C%22">Weidle C</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Carr+KD%22">Carr KD</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bettin+E%22">Bettin E</searchLink>; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Kymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Trejos+AT%22">Trejos AT</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Majumder+S%22">Majumder S</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kokane+S%22">Kokane S</searchLink>; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Stevens+A%22">Stevens A</searchLink>; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Muratspahić+E%22">Muratspahić E</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Schlichthaerle+T%22">Schlichthaerle T</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Expòsit+M%22">Expòsit M</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lamb+M%22">Lamb M</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Azcárraga+Murray+AN%22">Azcárraga Murray AN</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ravichandran+R%22">Ravichandran R</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Williams+EC%22">Williams EC</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+S%22">Hu S</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Stuart+L%22">Stuart L</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Grillová+L%22">Grillová L</searchLink>; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Thomson+NR%22">Thomson NR</searchLink>; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Landreh+M%22">Landreh M</searchLink>; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Chang+P%22">Chang P</searchLink>; Kymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Giacani+L%22">Giacani L</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Caimano+MJ%22">Caimano MJ</searchLink>; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hawley+KL%22">Hawley KL</searchLink>; Department of Pediatrics, UConn Health, Farmington, CT, USA.; Department of Medicine, UConn Health, Farmington, CT, USA.; Division of Infectious Diseases and Immunology, Connecticut Children's, Hartford CT, USA.; Department of Research, Connecticut Children's Research Institute, Hartford CT, USA.<br /><searchLink fieldCode="AU" term="%22King+NP%22">King NP</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Jul 02; Vol. 393 (6806), pp. eadr3817. <i>Date of Electronic Publication: </i>2026 Jul 02.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42391386
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.adr3817
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: eadr3817
    Titles:
      – TitleFull: Membrane protein solubilization and structure determination using de novo-designed proteins.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mihaljević L
      – PersonEntity:
          Name:
            NameFull: Kim DE
      – PersonEntity:
          Name:
            NameFull: Bandawane PD
      – PersonEntity:
          Name:
            NameFull: Eisenach HE
      – PersonEntity:
          Name:
            NameFull: Borst AJ
      – PersonEntity:
          Name:
            NameFull: Courbet A
      – PersonEntity:
          Name:
            NameFull: Weidle C
      – PersonEntity:
          Name:
            NameFull: Carr KD
      – PersonEntity:
          Name:
            NameFull: Bettin E
      – PersonEntity:
          Name:
            NameFull: Liu Q
      – PersonEntity:
          Name:
            NameFull: Trejos AT
      – PersonEntity:
          Name:
            NameFull: Majumder S
      – PersonEntity:
          Name:
            NameFull: Kokane S
      – PersonEntity:
          Name:
            NameFull: Stevens A
      – PersonEntity:
          Name:
            NameFull: Muratspahić E
      – PersonEntity:
          Name:
            NameFull: Schlichthaerle T
      – PersonEntity:
          Name:
            NameFull: Expòsit M
      – PersonEntity:
          Name:
            NameFull: Li X
      – PersonEntity:
          Name:
            NameFull: Lamb M
      – PersonEntity:
          Name:
            NameFull: Azcárraga Murray AN
      – PersonEntity:
          Name:
            NameFull: Ravichandran R
      – PersonEntity:
          Name:
            NameFull: Williams EC
      – PersonEntity:
          Name:
            NameFull: Hu S
      – PersonEntity:
          Name:
            NameFull: Stuart L
      – PersonEntity:
          Name:
            NameFull: Grillová L
      – PersonEntity:
          Name:
            NameFull: Thomson NR
      – PersonEntity:
          Name:
            NameFull: Landreh M
      – PersonEntity:
          Name:
            NameFull: Chang P
      – PersonEntity:
          Name:
            NameFull: Giacani L
      – PersonEntity:
          Name:
            NameFull: Caimano MJ
      – PersonEntity:
          Name:
            NameFull: Hawley KL
      – PersonEntity:
          Name:
            NameFull: King NP
      – PersonEntity:
          Name:
            NameFull: Baker D
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 07
              Text: 2026 Jul 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1095-9203
          Numbering:
            – Type: volume
              Value: 393
            – Type: issue
              Value: 6806
          Titles:
            – TitleFull: Science (New York, N.Y.)
              Type: main
ResultId 1