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Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP.

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Title: Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP.
Authors: Kuser-Abali G; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia., Noguchi F; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia., Zhao P; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia., Szeto P; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia., Zhang Y; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia., Huang C; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia., Barlow CK; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia., Pomilio G; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3004, Australia., Boudes M; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Chew C; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia., Moghaddam SM; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia., Leece I; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia., Cheung JG; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia., Ameratunga M; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia., Wong NC; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia., Andrews MC; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia., Schittenhelm RB; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia., Wei A; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3004, Australia., Naranbhai V; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia., Davidovich C; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Shackleton M; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia. Electronic address: mark.shackleton@monash.edu.
Source: Molecular cell [Mol Cell] 2026 Jul 02; Vol. 86 (13), pp. 2521-2538.e10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP.
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  Data: <searchLink fieldCode="AU" term="%22Kuser-Abali+G%22">Kuser-Abali G</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Noguchi+F%22">Noguchi F</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Szeto+P%22">Szeto P</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Barlow+CK%22">Barlow CK</searchLink>; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Pomilio+G%22">Pomilio G</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Boudes+M%22">Boudes M</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Chew+C%22">Chew C</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Moghaddam+SM%22">Moghaddam SM</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Leece+I%22">Leece I</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Cheung+JG%22">Cheung JG</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Ameratunga+M%22">Ameratunga M</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Wong+NC%22">Wong NC</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Andrews+MC%22">Andrews MC</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Schittenhelm+RB%22">Schittenhelm RB</searchLink>; Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Wei+A%22">Wei A</searchLink>; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Naranbhai+V%22">Naranbhai V</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia.<br /><searchLink fieldCode="AU" term="%22Davidovich+C%22">Davidovich C</searchLink>; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.<br /><searchLink fieldCode="AU" term="%22Shackleton+M%22">Shackleton M</searchLink>; Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia. Electronic address: mark.shackleton@monash.edu.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2026 Jul 02; Vol. 86 (13), pp. 2521-2538.e10.
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              Text: 2026 Jul 02
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