Cost-effectiveness of the sFlt-1/PlGF ratio and telemonitoring in managing suspected pre-eclampsia: protocol for the PREPARE II randomised controlled trial.

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Title: Cost-effectiveness of the sFlt-1/PlGF ratio and telemonitoring in managing suspected pre-eclampsia: protocol for the PREPARE II randomised controlled trial.
Authors: Wind M; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands m.wind@lumc.nl., Peters A; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands., van den Akker-van Marle ME; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands., Vanden Auweele K; Patient' Association, The Hellp Foundation, Zwolle, Overijssel, the Netherlands., van Bodegom-Vos L; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands., Boekhorst F; Department of Obstetrics, Groene Hart Hospital, Gouda, Zuid-Holland, the Netherlands., Cobbaert CM; Department of Clinical Chemistry, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands., Hermes W; Department of Obstetrics, Haaglanden Medical Center, The Hague, Zuid-Holland, the Netherlands., Van Hoorn ME; Department of Obstetrics, Haga Hospital, The Hague, Zuid-Holland, the Netherlands., Van Den Haak L; Department of Obstetrics, Reinier de Graaf Hospital, Delft, Zuid-Holland, the Netherlands., Lutke Holzik M; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands., Tsonaka R; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands., Van Wyk L; Department of Obstetrics, Alrijne Hospital, Leiden, Zuid-Holland, the Netherlands., Teng YKO; Department of Nephrology, Leiden University Medical Center, Leiden, ZH, the Netherlands., Sueters M; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.
Source: BMJ open [BMJ Open] 2026 Jul 02; Vol. 16 (7), pp. e113516. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cost-effectiveness of the sFlt-1/PlGF ratio and telemonitoring in managing suspected pre-eclampsia: protocol for the PREPARE II randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Wind+M%22">Wind M</searchLink>; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands m.wind@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Peters+A%22">Peters A</searchLink>; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Akker-van+Marle+ME%22">van den Akker-van Marle ME</searchLink>; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vanden+Auweele+K%22">Vanden Auweele K</searchLink>; Patient' Association, The Hellp Foundation, Zwolle, Overijssel, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Bodegom-Vos+L%22">van Bodegom-Vos L</searchLink>; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boekhorst+F%22">Boekhorst F</searchLink>; Department of Obstetrics, Groene Hart Hospital, Gouda, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cobbaert+CM%22">Cobbaert CM</searchLink>; Department of Clinical Chemistry, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hermes+W%22">Hermes W</searchLink>; Department of Obstetrics, Haaglanden Medical Center, The Hague, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Van+Hoorn+ME%22">Van Hoorn ME</searchLink>; Department of Obstetrics, Haga Hospital, The Hague, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Van+Den+Haak+L%22">Van Den Haak L</searchLink>; Department of Obstetrics, Reinier de Graaf Hospital, Delft, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lutke+Holzik+M%22">Lutke Holzik M</searchLink>; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tsonaka+R%22">Tsonaka R</searchLink>; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Van+Wyk+L%22">Van Wyk L</searchLink>; Department of Obstetrics, Alrijne Hospital, Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Teng+YKO%22">Teng YKO</searchLink>; Department of Nephrology, Leiden University Medical Center, Leiden, ZH, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sueters+M%22">Sueters M</searchLink>; Department of Obstetrics, Leiden University Medical Center, Leiden, Zuid-Holland, the Netherlands.
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              Text: 2026 Jul 02
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