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Paradoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains.

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Title: Paradoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains.
Authors: Reber V; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Keller S; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Loosli SA; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Arima Y; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland., Kleele T; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland., Picotti P; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland., Gstaiger M; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland. matthias.gstaiger@imsb.biol.ethz.ch.
Source: Molecular systems biology [Mol Syst Biol] 2026 Jul 02. Date of Electronic Publication: 2026 Jul 02.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Reber+V%22">Reber V</searchLink>; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Keller+S%22">Keller S</searchLink>; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Loosli+SA%22">Loosli SA</searchLink>; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Arima+Y%22">Arima Y</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kleele+T%22">Kleele T</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Picotti+P%22">Picotti P</searchLink>; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gstaiger+M%22">Gstaiger M</searchLink>; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland. matthias.gstaiger@imsb.biol.ethz.ch.
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  Data: <searchLink fieldCode="JN" term="%22101235389%22">Molecular systems biology</searchLink> [Mol Syst Biol] 2026 Jul 02. <i>Date of Electronic Publication: </i>2026 Jul 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22EMBO+Press%22">EMBO Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101235389 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1744-4292 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217444292%22">17444292 </searchLink><i>NLM ISO Abbreviation: </i>Mol Syst Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s44320-026-00229-2
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              Text: 2026 Jul 02
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