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Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: Results from the IGNITE study.

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Title: Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: Results from the IGNITE study.
Authors: Solis-Urra P; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar, 2531015, Chile., Sewell KR; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, 6150, Australia., Collins AM; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA., Kang C; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Huang H; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA., Grove G; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Wan L; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA., Norling AM; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Kramer AF; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, IL, 61801, USA., McAuley E; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, IL, 61801, USA.; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Burns JM; Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA., Hillman CH; Department of Psychology, Northeastern University, Boston, MA, 02115, USA.; Institute for Cognitive & Brain Health, Northeastern University, Boston, MA, USA.; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, 02115, USA., Vidoni ED; Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA., Marsland AL; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Ilyas Kamboh M; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Szabo-Reed A; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA., Rogers RJ; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA., Forman DE; Department of Medicine (Cardiology and Geriatrics), University of Pittsburgh, and Pittsburgh Geriatrics, Research, Education and Clinical Care (GRECC), Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA., Billinger SA; Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA., Jakicic JM; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA., Erickson KI; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA., Oberlin LE; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Department of Psychiatry, Weill Cornell Medicine, New York, NY, 10065, USA.
Source: Brain, behavior, & immunity - health [Brain Behav Immun Health] 2026 Jun 25; Vol. 55, pp. 101291. Date of Electronic Publication: 2026 Jun 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101759062 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3546 (Electronic) Linking ISSN: 26663546 NLM ISO Abbreviation: Brain Behav Immun Health Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Solis-Urra+P%22">Solis-Urra P</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar, 2531015, Chile.<br /><searchLink fieldCode="AU" term="%22Sewell+KR%22">Sewell KR</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, 6150, Australia.<br /><searchLink fieldCode="AU" term="%22Collins+AM%22">Collins AM</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kang+C%22">Kang C</searchLink>; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Grove+G%22">Grove G</searchLink>; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Wan+L%22">Wan L</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Norling+AM%22">Norling AM</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kramer+AF%22">Kramer AF</searchLink>; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, IL, 61801, USA.<br /><searchLink fieldCode="AU" term="%22McAuley+E%22">McAuley E</searchLink>; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, IL, 61801, USA.; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.<br /><searchLink fieldCode="AU" term="%22Burns+JM%22">Burns JM</searchLink>; Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Hillman+CH%22">Hillman CH</searchLink>; Department of Psychology, Northeastern University, Boston, MA, 02115, USA.; Institute for Cognitive & Brain Health, Northeastern University, Boston, MA, USA.; Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Vidoni+ED%22">Vidoni ED</searchLink>; Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Marsland+AL%22">Marsland AL</searchLink>; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.<br /><searchLink fieldCode="AU" term="%22Ilyas+Kamboh+M%22">Ilyas Kamboh M</searchLink>; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15261, USA.<br /><searchLink fieldCode="AU" term="%22Szabo-Reed+A%22">Szabo-Reed A</searchLink>; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+RJ%22">Rogers RJ</searchLink>; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Forman+DE%22">Forman DE</searchLink>; Department of Medicine (Cardiology and Geriatrics), University of Pittsburgh, and Pittsburgh Geriatrics, Research, Education and Clinical Care (GRECC), Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Billinger+SA%22">Billinger SA</searchLink>; Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Jakicic+JM%22">Jakicic JM</searchLink>; Department of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Erickson+KI%22">Erickson KI</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Oberlin+LE%22">Oberlin LE</searchLink>; AdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.; Department of Psychiatry, Weill Cornell Medicine, New York, NY, 10065, USA.
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