Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.
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| Title: | Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase. |
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| Authors: | Zhang Z; State Key Laboratory of Biotherapy and Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China., Kumar V; Emeritus Group Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.; Department of Structural Dynamics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany., Panta S; Department of Structural Dynamics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany., Zhong J; State Key Laboratory of Biotherapy and Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China., Dybkov O; Bioanalytical Mass Spectrometry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany., Dong H; State Key Laboratory of Biotherapy and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China., Kastner B; Emeritus Group Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany., Urlaub H; Bioanalytical Mass Spectrometry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.; Bioanalytics Group, Institute for Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany., Stark H; Department of Structural Dynamics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. hstark1@gwdg.de., Lührmann R; Emeritus Group Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. reinhard.luehrmann@mpinat.mpg.de. |
| Source: | Nature communications [Nat Commun] 2026 Jul 03; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 03. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-75109-2 |
