Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.

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Title: Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.
Authors: Wei JY; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Liu ZW; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Lu QS; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China., Qin YJ; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., He YZ; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Zheng YQ; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Lin YC; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Yang DH; New York College of Traditional Chinese Medicine, Mineola, NY, USA., Li YH; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Huang YX; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. hyx6610@163.com.
Source: Leukemia [Leukemia] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-026-03021-1