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Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.

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Title: Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.
Authors: Wei JY; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Liu ZW; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Lu QS; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China., Qin YJ; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., He YZ; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Zheng YQ; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Lin YC; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Yang DH; New York College of Traditional Chinese Medicine, Mineola, NY, USA., Li YH; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Huang YX; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. hyx6610@163.com.
Source: Leukemia [Leukemia] 2026 Jul 03. Date of Electronic Publication: 2026 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.
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  Data: <searchLink fieldCode="AU" term="%22Wei+JY%22">Wei JY</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Liu+ZW%22">Liu ZW</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Lu+QS%22">Lu QS</searchLink>; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Qin+YJ%22">Qin YJ</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22He+YZ%22">He YZ</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zheng+YQ%22">Zheng YQ</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Lin+YC%22">Lin YC</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Yang+DH%22">Yang DH</searchLink>; New York College of Traditional Chinese Medicine, Mineola, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+YH%22">Li YH</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Huang+YX%22">Huang YX</searchLink>; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. hyx6610@163.com.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2026 Jul 03. <i>Date of Electronic Publication: </i>2026 Jul 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41375-026-03021-1
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      – Code: eng
        Text: English
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      – TitleFull: Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.
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            – D: 03
              M: 07
              Text: 2026 Jul 03
              Type: published
              Y: 2026
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