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A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver.

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Title: A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver.
Authors: Mohammed S; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Jiang C; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Pennington T; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Bhaskaran S; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Ohene-Marfo P; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Kneuper KF; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Georgescu C; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Pitts K; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Tran A; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Peng Z; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA., Singh A; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA., Yang Z; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA., Li T; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Hannafon B; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Obstetrics and Gynecology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Houchen C; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Wren JD; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Yabluchanskiy A; Department of Neurosurgery, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Galvan V; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Oklahoma Center for Geroscience & Healthy Brain Aging, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA., Ahsan N; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA.; Mass Spectrometry, Proteomics and Metabolomics Core Facility, Stephenson Life Sciences Research Center, The University of Oklahoma, Norman, Oklahoma, USA., Kinter M; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Lewis TL Jr; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Deepa SS; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Oklahoma Center for Geroscience & Healthy Brain Aging, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Source: Aging cell [Aging Cell] 2026 Jul; Vol. 25 (7), pp. e70618.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mohammed+S%22">Mohammed S</searchLink>; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+C%22">Jiang C</searchLink>; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Pennington+T%22">Pennington T</searchLink>; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Bhaskaran+S%22">Bhaskaran S</searchLink>; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Ohene-Marfo+P%22">Ohene-Marfo P</searchLink>; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Kneuper+KF%22">Kneuper KF</searchLink>; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Georgescu+C%22">Georgescu C</searchLink>; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Pitts+K%22">Pitts K</searchLink>; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Tran+A%22">Tran A</searchLink>; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Peng+Z%22">Peng Z</searchLink>; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Singh+A%22">Singh A</searchLink>; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Hannafon+B%22">Hannafon B</searchLink>; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Department of Obstetrics and Gynecology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Houchen+C%22">Houchen C</searchLink>; Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Wren+JD%22">Wren JD</searchLink>; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Yabluchanskiy+A%22">Yabluchanskiy A</searchLink>; Department of Neurosurgery, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Galvan+V%22">Galvan V</searchLink>; Department of Biochemistry & Physiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.; Oklahoma Center for Geroscience & Healthy Brain Aging, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Ahsan+N%22">Ahsan N</searchLink>; Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma, USA.; 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