Repurposing Metformin to Promote Fracture Callus Maturation via AMPK-Driven Metabolic Activation.
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| Title: | Repurposing Metformin to Promote Fracture Callus Maturation via AMPK-Driven Metabolic Activation. |
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| Authors: | Pastukh V; MechanoBiology Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Zhang J; MechanoBiology Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Alexander PG; Joint Tissue Development and Engineering Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Bhargava S; MechanoBiology Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Shams A; MechanoBiology Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Zhao C; MechanoBiology Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Hogan MV; MechanoBiology Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Wang JH; MechanoBiology Laboratory, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. |
| Source: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2026 Jul; Vol. 44 (7), pp. e70246. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 8404726 Publication Model: Print Cited Medium: Internet ISSN: 1554-527X (Electronic) Linking ISSN: 07360266 NLM ISO Abbreviation: J Orthop Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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