Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.
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| Title: | Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance. |
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| Authors: | Menze I; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. inga.menze@dzne.de.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany. inga.menze@dzne.de., Bernal J; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Department Artificial Intelligence in Biomedical Engineering (AIBE), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.; Institute for Neuroscience and Cardiovascular Research, Row Fogo Centre for Research into Ageing and The Brain, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK.; Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Kievit RA; Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Centre, Nijmegen, The Netherlands., Tripathi KP; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Kaleck T; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Yakupov R; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany., Altenstein S; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Bartels C; Department of Psychiatry and Psychotherapy, University Medical Centre Goettingen, Georg August University of Goettingen, Goettingen, Germany., Buerger K; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Butryn M; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany., Dechent P; MR-Research in Neurosciences, Department of Cognitive Neurology, University Medical Centre Goettingen, Goettingen, Germany., Ewers M; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Fliessbach K; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn, University Hospital Bonn, Bonn, Germany., Frommann I; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn, University Hospital Bonn, Bonn, Germany., Gemenetzi M; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Glanz W; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany., Gref D; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany., Hellmann-Regen J; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany., Hetzer S; Berlin Centre for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany., Incesoy EI; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Vivantes Klinikum Am Urban, Department of Psychiatry, Psychotherapy, and Psychosomatics, Vivantes Urban Hospital, Berlin, Germany., Janowitz D; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Kiliman I; German Centre for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Kleineidam L; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn, University Hospital Bonn, Bonn, Germany., Kronmüller MT; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany., Laske C; German Centre for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., van Lent DM; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA., Lüsebrink F; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Perneczky R; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, Charing Cross Hospital, London, UK., Peters O; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, ECRC Experimental and Clinical Research Center, Berlin, Germany., Preis L; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany., Priller J; Institute for Neuroscience and Cardiovascular Research, Row Fogo Centre for Research into Ageing and The Brain, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK.; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Centre for Mental Health (DZPG), Munich, Germany., Rauchmann BS; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.; Department of Neuroradiology, University Hospital LMU, Munich, Germany., Rostamzadeh A; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany., Roeske S; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany., Schott BH; Department of Psychiatry and Psychotherapy, University Medical Centre Goettingen, Georg August University of Goettingen, Goettingen, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Leibniz Institute for Neurobiology, Magdeburg, Germany., Schneider A; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn, University Hospital Bonn, Bonn, Germany., Sodenkamp S; German Centre for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Spottke A; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Spruth EJ; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Stark M; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn, University Hospital Bonn, Bonn, Germany., Teipel S; German Centre for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Wagner M; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn, University Hospital Bonn, Bonn, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Centre Goettingen, Georg August University of Goettingen, Goettingen, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Campus Universitario de Santiago, Aveiro, Portugal., Jessen F; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn, University Hospital Bonn, Bonn, Germany.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Schreiber S; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Department of Neurology, Otto von Guericke University Magdeburg, Magdeburg, Germany., Düzel E; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Cognitive Neuroscience, University College London, London, UK., Ziegler G; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany. |
| Source: | Nature communications [Nat Commun] 2026 Jul 04; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 04. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-74957-2 |
