Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.

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Title: Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.
Authors: Walker SM; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Loutan AJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Tchesnokov EP; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Kocincova D; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada., Gordon CJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada., Escobedo RA; Texas Biomedical Research Institute, San Antonio, TX, USA., Jackson N; Texas Biomedical Research Institute, San Antonio, TX, USA., Vogel OA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Morsheimer K; Department of Virology, Microbiology and Immunology, Boston University, Boston, MA, USA., Park S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Gharpure A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Urbano I; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Heacock M; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Chen Z; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Pathak K; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Wolff KC; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Huerta L; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Bakowski MA; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Riva L; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Gupta AK; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Yu C; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Das K; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada; Molecular Structural and Translational Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium., Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, TX, USA., Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Davey R; Department of Virology, Microbiology and Immunology, Boston University, Boston, MA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Chanda S; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Chatterjee AK; Calibr-Skaggs Institute for Innovative Medicines, The Scripps Research Institute, La Jolla, CA, USA., Götte M; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada. Electronic address: gotte@ualberta.ca.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Jul 06, pp. 113316. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2026.113316