PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation.
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| Title: | PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation. |
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| Authors: | Yao Z; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China., Wang W; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Tang K; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Yang Y; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Ren S; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Weng Y; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Ma L; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Chen D; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Gu H; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Wan J; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Liu Z; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Zheng Y; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Li C; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. chaohuili2021@gzhmu.edu.cn., Luo F; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. akidreams@smu.edu.cn., Zhao XY; State Key Laboratory of Organ Failure Research, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Key Laboratory of Mental Health of the Ministry of Education, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, Guangdong, China. zhaoxiaoyang@smu.edu.cn.; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Department of Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; National Clinical Research Center for Kidney Disease, Guangzhou, China. zhaoxiaoyang@smu.edu.cn., Fan Y; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. yongfan011@gzhmu.edu.cn. |
| Source: | Cell regeneration (London, England) [Cell Regen] 2026 Jul 07; Vol. 15 (1). Date of Electronic Publication: 2026 Jul 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: China NLM ID: 101627311 Publication Model: Electronic Cited Medium: Print ISSN: 2045-9769 (Print) Linking ISSN: 20459769 NLM ISO Abbreviation: Cell Regen Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-9769 |
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| DOI: | 10.1186/s13619-026-00293-x |
