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PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation.

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Title: PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation.
Authors: Yao Z; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China., Wang W; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Tang K; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Yang Y; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Ren S; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Weng Y; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Ma L; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Chen D; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Gu H; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Wan J; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Liu Z; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Zheng Y; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Li C; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. chaohuili2021@gzhmu.edu.cn., Luo F; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. akidreams@smu.edu.cn., Zhao XY; State Key Laboratory of Organ Failure Research, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Key Laboratory of Mental Health of the Ministry of Education, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, Guangdong, China. zhaoxiaoyang@smu.edu.cn.; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Department of Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; National Clinical Research Center for Kidney Disease, Guangzhou, China. zhaoxiaoyang@smu.edu.cn., Fan Y; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. yongfan011@gzhmu.edu.cn.
Source: Cell regeneration (London, England) [Cell Regen] 2026 Jul 07; Vol. 15 (1). Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: China NLM ID: 101627311 Publication Model: Electronic Cited Medium: Print ISSN: 2045-9769 (Print) Linking ISSN: 20459769 NLM ISO Abbreviation: Cell Regen Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation.
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  Data: <searchLink fieldCode="AU" term="%22Yao+Z%22">Yao Z</searchLink>; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tang+K%22">Tang K</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ren+S%22">Ren S</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Weng+Y%22">Weng Y</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gu+H%22">Gu H</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wan+J%22">Wan J</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. chaohuili2021@gzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Luo+F%22">Luo F</searchLink>; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. akidreams@smu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhao+XY%22">Zhao XY</searchLink>; State Key Laboratory of Organ Failure Research, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Key Laboratory of Mental Health of the Ministry of Education, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou, Guangdong, China. zhaoxiaoyang@smu.edu.cn.; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; Department of Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.; National Clinical Research Center for Kidney Disease, Guangzhou, China. zhaoxiaoyang@smu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. yongfan011@gzhmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101627311%22">Cell regeneration (London, England)</searchLink> [Cell Regen] 2026 Jul 07; Vol. 15 (1). <i>Date of Electronic Publication: </i>2026 Jul 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101627311 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2045-9769 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220459769%22">20459769 </searchLink><i>NLM ISO Abbreviation: </i>Cell Regen <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42410128
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1186/s13619-026-00293-x
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      – Code: eng
        Text: English
    Titles:
      – TitleFull: PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation.
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              Text: 2026 Jul 07
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