Highly Stereoselective Synthesis of the Chiral Fungicide's Intermediate (R)-N-(2,6-Dimethylphenyl) Aminopropionic Acid Methyl Ester via an Esterase-Lipase Cascade.

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Title: Highly Stereoselective Synthesis of the Chiral Fungicide's Intermediate (R)-N-(2,6-Dimethylphenyl) Aminopropionic Acid Methyl Ester via an Esterase-Lipase Cascade.
Authors: Yu X; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.; State Key Laboratory of Green Chemical Synthesis and Conversion, Zhejiang University of Technology, Hangzhou 310014, China., Qian Z; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China., Tu Z; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China., Zhou M; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China., Sun Y; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China., Liu X; Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environment and Sustainable Development, Beihai 536000 Guangxi, China.; Fourth Institute of Oceanography, Ministry of Natural Resources, The First Keyan Rd of Marine Scientific Research Innovation Park, Haijing Avenue, Beihai 536000 Guangxi, China., Wang Z; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.; State Key Laboratory of Green Chemical Synthesis and Conversion, Zhejiang University of Technology, Hangzhou 310014, China., Zhang Y; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.; State Key Laboratory of Green Chemical Synthesis and Conversion, Zhejiang University of Technology, Hangzhou 310014, China.
Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Jul 15; Vol. 74 (27), pp. 21345-21353. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5118
DOI:10.1021/acs.jafc.5c17439