Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant.

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Title: Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant.
Authors: Hang C; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Shi X; Department of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhao T; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Li J; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Zhang T; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Chen Z; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Wu Y; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China., Zhou Y; School of Pharmacy, Ningxia Medical University, Yinchuan, China., Wu S; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Jiao Y; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Wang Y; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Chen H; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Sun J; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China., Li T; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China., Zhang J; Department of Pharmaceutical and Artificial-Intelligence Sciences, Institute of Medical Artificial Intelligence, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Jia H; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China., Wan X; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Li X; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Chen J; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China., Yu B; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China., Sun X; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; National Clinical Research Center for Eye Diseases, Shanghai, China.; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China.; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.; Shanghai Gene Therapy Center, Shanghai, China.
Source: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2026 Jul 01; Vol. 67 (8), pp. 23.
Publication Type: Journal Article
Journal Info: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1552-5783
DOI:10.1167/iovs.67.8.23