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ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.

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Title: ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.
Authors: Tu X; Department of Radiation Oncology, Mayo Cinic, Rochester, United States of America., Zeng X; Department of Oncology, Mayo Clinic, Rochester, United States of America., Sun Y; Department of Oncology, Mayo Clinic, Rochester, United States of America., Ouyang Y; Department of Oncology, Mayo Clinic, Rochester, United States of America., Zhu L; Department of Oncology, Mayo Clinic, Rochester, United States of America., Yin P; Department of Oncology, Mayo Clinic, Rochester, United States of America., Pavelko KD; Department of Immunology, Mayo Clinic, Rochester, United States of America., Leon-Ferre RA; Department of Medical Oncology, Mayo Clinic, Rochester, United States of America., Jiang Y; Department of Oncology, Mayo Clinic, Rochester, United States of America., Dong H; Departments of Urology and Immunology, Mayo Clinic, Rochester, United States of America., Carter JM; Laboratory Medicine and Pathology Department, University of Alberta, Edmonton, Canada., Zhu S; Department of Oncology, Mayo Cinic, Rochester, United States of America., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America., Wang L; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, United States of America., Huang J; Department of Oncology, Mayo Cinic, Rochester, United States of America., Luo K; Department of Oncology, Mayo Clinic, Rochester, United States of America., Han Y; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America., Wu Z; Department of Oncology, Mayo Cinic, Rochester, United States of America., Lou Z; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, United States of America., Mutter RW; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1558-8238
DOI:10.1172/JCI192285