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ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.

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Title: ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.
Authors: Tu X; Department of Radiation Oncology, Mayo Cinic, Rochester, United States of America., Zeng X; Department of Oncology, Mayo Clinic, Rochester, United States of America., Sun Y; Department of Oncology, Mayo Clinic, Rochester, United States of America., Ouyang Y; Department of Oncology, Mayo Clinic, Rochester, United States of America., Zhu L; Department of Oncology, Mayo Clinic, Rochester, United States of America., Yin P; Department of Oncology, Mayo Clinic, Rochester, United States of America., Pavelko KD; Department of Immunology, Mayo Clinic, Rochester, United States of America., Leon-Ferre RA; Department of Medical Oncology, Mayo Clinic, Rochester, United States of America., Jiang Y; Department of Oncology, Mayo Clinic, Rochester, United States of America., Dong H; Departments of Urology and Immunology, Mayo Clinic, Rochester, United States of America., Carter JM; Laboratory Medicine and Pathology Department, University of Alberta, Edmonton, Canada., Zhu S; Department of Oncology, Mayo Cinic, Rochester, United States of America., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America., Wang L; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, United States of America., Huang J; Department of Oncology, Mayo Cinic, Rochester, United States of America., Luo K; Department of Oncology, Mayo Clinic, Rochester, United States of America., Han Y; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America., Wu Z; Department of Oncology, Mayo Cinic, Rochester, United States of America., Lou Z; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, United States of America., Mutter RW; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.
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  Data: <searchLink fieldCode="AU" term="%22Tu+X%22">Tu X</searchLink>; Department of Radiation Oncology, Mayo Cinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; Department of Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Ouyang+Y%22">Ouyang Y</searchLink>; Department of Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Department of Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Yin+P%22">Yin P</searchLink>; Department of Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Pavelko+KD%22">Pavelko KD</searchLink>; Department of Immunology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Leon-Ferre+RA%22">Leon-Ferre RA</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Department of Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Dong+H%22">Dong H</searchLink>; Departments of Urology and Immunology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Carter+JM%22">Carter JM</searchLink>; Laboratory Medicine and Pathology Department, University of Alberta, Edmonton, Canada.<br /><searchLink fieldCode="AU" term="%22Zhu+S%22">Zhu S</searchLink>; Department of Oncology, Mayo Cinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Sarkaria+JN%22">Sarkaria JN</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Oncology, Mayo Cinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Luo+K%22">Luo K</searchLink>; Department of Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Oncology, Mayo Cinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Lou+Z%22">Lou Z</searchLink>; Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, United States of America.<br /><searchLink fieldCode="AU" term="%22Mutter+RW%22">Mutter RW</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, United States of America.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
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        Value: 10.1172/JCI192285
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        Text: English
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              Text: 2026 Jul 07
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