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Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake.

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Title: Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake.
Authors: Chen B; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Prabhu A; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Li G; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Kaltenbach A; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Wang Y; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Shakir G; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Natarelli L; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Megens R; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Netherlands., Jansen Y; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Ramanathan S; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Geiger M; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Faussner A; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Hristov M; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Richter D; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians-Universität Munich, Planegg-Martinsried, Germany., Di X; Department of Molecular Physiology, Leiden University and Oncode Institute, Leiden, Netherlands., van der Stelt M; Department of Molecular Physiology, Leiden University and Oncode Institute, Leiden, Netherlands., Triantafyllidou V; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Li Z; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany., Sachs N; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany., Paloschi V; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany., Maegdefessel L; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany., Hofmann SM; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum Munich, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Medicine IV, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Schifferer M; German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany., Simons M; German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.; Institute for Stroke and Dementia Research, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Weber C; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands., Santovito D; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Herzig S; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes and Cancer, Helmholtz Zentrum Munich, Neuherberg, Germany.; Chair Molecular Metabolic Control, Technical University Munich (TUM), Munich, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany., Guillamat Prats R; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany., Steffens S; Institute for Cardiovascular Prevention, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universität Munich, Munich, Germany. Sabine.Steffens@med.uni-muenchen.de.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Sabine.Steffens@med.uni-muenchen.de.; German Center for Diabetes Research (DZD), Neuherberg, Germany. Sabine.Steffens@med.uni-muenchen.de.; Institute for Diabetes and Cancer, Helmholtz Zentrum Munich, Neuherberg, Germany. Sabine.Steffens@med.uni-muenchen.de.
Source: Nature communications [Nat Commun] 2026 Jul 07; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-75214-2